What is Sildenafil? Know These Things Before You Buy Sildenafil
This sildenafil guide gives us an introduction to sildenafil, including its origin, indicated uses, and sildenafil dosage. Our comprehensive sildenafil review will also discuss what available research knows about sildenafil benefits and side effects.
Sildenafil was originally created by Pfizer chemists in England, for the intention of treating high blood pressure (hypertension) and chest pain associated with heart disease (angina). Phase I clinical trials showed that instead of effectively benefiting angina, sildenafil is effective at promoting penile erections.
How Sildenafil Works:
Sildenafil research has shown that it is effective in ameliorating symptoms of erectile dysfunction in males. Sildenafil belongs to a class of compounds called phosphodiesterase 5 (PDE5) inhibitors. These compounds block an enzyme called phosphodiesterase type-5, which in turn increases nitric oxide’s effects in the penile tissues. As a result, Sildenafil causes an increase in blood flow to the penis, but does not directly promote sexual arousal.
Sildenafil is also used with some success in males and females to reduce pulmonary arterial high blood pressure (high blood pressure within the arteries of the lungs), improving the heart’s ability to pump sufficient blood through the lungs. In this case, Sildenafil works also via PDE5 enzyme inhibition to allow more nitric oxide to dilate the blood vessels in these arteries.
Individuals with diabetes, anti-depressant induced sexual dysfunction, and other circulatory issues often find interest in sildenafil for promoting erectile function.
Sildenafil is primarily metabolized by the liver via CPY450 (cytochrome p450) enzymes, and its primary metabolite is responsible for up to 20% of its effects.
Sildenafil Use, Effects and Side Effects:
Many people buy liquid sildenafil or Sildenafil pills (capsules or tablets). It is important to buy sildenafil that is accurate and of high potency and purity, particularly when determining the best liquid sildenafil dose. Many individuals chose to buy liquid sildenafil online, particularly in liquid form for research purposes. There are many illicit online sildenafil sources, which promote its recreational use, offer counterfeit sildenafil, or adulterate “sexual health” supplements with sildenafil.
According to available research, a commonly used effective Sildenafil dose can vary between individuals, ranging from 25mg to 100mg orally.
Sildenafil typically begins to work between 15 and 60 minutes after oral consumption. With liquid sildenafil, it is easier to absorb sildenafil faster sublingually (under the tongue). Research has shown that sildenafil is less effective when taken with food, particularly a meal higher in fat content.
It is commonly known that taking sildenafil alongside other compounds or medications (particularly other blood pressure-lowering compounds) can create undesirable interactions. Reported common sildenafil side effects include too strong a drop in blood pressure, headaches, blurred vision, and digestive distress, to name a few. Some compounds can interfere with sildenafil metabolism, which will increase its plasma concentrations and pharmacologic effects to potentially dangerous levels.
It is advised to consult with a physician before taking sildenafil and to exercise caution when researching sildenafil.
Buy Sildenafil from ELV Bioscience for research or laboratory use. Our research chemicals are made in an ISO9001 cGMP facility within the United States under strict purity, potency, and quality control standards.
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FDA Warns Consumers About Dangerous Ingredients in “Dietary Supplements” Promoted for Sexual Enhancement
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