What is CBD (Cannabidiol)? Learn More About CBD Benefits

Buy CBD Online
CBD (Cannabidiol)

Buy CBD (Cannabidiol)

What is CBD (Cannabidiol)?

Cannabidiol (CBD) is often available in the form of CBD oil. CBD is a well-known botanical extract from the Cannabis Sativa plant (particularly industrial hemp variety). Aside from CBD oil, CBD can also be found in crystalline isolate, full spectrum extract, and CBD distillate form. Also, 98% pure CBD is available as a US FDA approved drug product indicated for two rare forms of pediatric refractory epilepsy. While available research is limited on CBD benefits, many proposed benefits of CBD oil and other CBD extracts are widely promoted.

CBD, which is an abbreviation for cannabidiol, belongs to a category of chemicals known as cannabinoids, which are native to the Cannabis Sativa plant. There are two common varieties of Cannabis Sativa. One is referred to as “marijuana,” which has been grown for high THC (Delta-9-Tetrahydrocannabinol content, and “hemp” which has been grown for food, textile, and now high CBD content and contains minimal THC content. CBD is the second most abundant and common of the (at least) 113 currently known. CBD (and cannabinoids) are poorly water soluble, but readily lipid (fat) soluble. As a result, CBD has limited oral absorption, in the range of approximately 10%, with 90% being wasted. Formulations such as ELV Bioscience’s research grade CBD uses a proprietary advanced liposomal technology which significantly enhances CBD bio-availability and absorption to promote more effective research.

CBD, unlike THC, does not have psychoactive properties. CBD and CBD oil uses would therefore vary from those of THC.

Despite widespread claims of many CBD health benefits, there is still very limited clinical research on cannabidiol. The U.S. Food and Drug Administration (FDA) approved a plant-derived 98% pure CBD isolate in June 2018 for pediatric patients that are two years of age and older, suffering from rare forms of refractory epilepsy. The two types of epilepsy are Dravet syndrome and Lennox-Gastaut syndrome. These diseases, and all refractory forms of epilepsy, do not respond well to the current standard of care drug options. Other than this FDA approved drug, CBD can only legally be used for research, regardless of its source. Even though the Farm Bill removed CBD from the Controlled Substance List, CBD is not permitted in foods, beverages, supplements, or cosmetics according to the Food, Drug, and Cosmetic Act. CBD is not DSHEA compliant (Dietary Supplement Health and Education Act).

CBD should not be purchased from any source except for a reputable research chemical supplier because there are many reports of terrible quality control. Most CBD products on the market do not contain the claimed amount of CBD, if they contain CBD at all.

Based on limited research, but plentiful anecdotal reports, here are some common CBD Benefits benefits:

CBD and Anxiety:

CBD has been studied to determine its effect on anxiety. The study compared CBD (cannabidiol) with placebo and a control (a benzodiazepine). According to the study, CBD was mildly effective at a dose of 300mg, not effective at 600mg, and produced anxiety in some participants at 900mg. This suggests a bell-curve in CBD’s efficacy in treating anxiety. More research is needed to further explore CBD and anxiety.

CBD and Pain:

There is a lot of interest among people and the pharmaceutical industry to explore Cannabidiol and other cannabinoids for their potential ability to reduce certain types of pain. While it is suggested to be unlikely that CBD or other cannabinoids can replace opioids for pain management, they are being investigated for adjunct treatment to help reduce use, abuse, and dependence on opioid medications. CBD is suggested to have anti-inflammatory properties, so it may be beneficial in treating pain that is a result of inflammation. CBD pain benefits are currently being further explored in clinical research.

CBD and Acne:

Based on limited research, CBD may help reduce acne formation due to its anti-inflammatory properties and ability to potentially reduce sebum production.

Acne affects both teenage and adult patients. It is believed to occur due to various factors such as genetic pre-disposition, bacteria, inflammation, hormonal imbalances, and dietary causes. Acne is characterized by an over-production of sebum, an oily secretion produced by sebaceous glands underneath the skin. Further research is needed to validate how CBD treats acne.

CBD and Neuroprotective Properties:

Available research shows that CBD acts on the endocannabinoid system in such a way that promotes neuroprotective properties. In fact, the NIH (National Institute of Health) has patents for Cannabinoids for use as neuroprotectants and antioxidants. While more research is needed, given that CBD is effective for calming the excitatory neurological activity that promotes seizures, it is reasonable to assume that CBD has neuroprotective properties as well.  

Buy CBD Online


REFERENCES:

Boggs, Douglas L; Nguyen, Jacques D; Morgenson, Daralyn; Taffe, Michael A; Ranganathan, Mohini (September 6, 2017). “Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol”. Neuropsychopharmacology. 43 (1): 142–154. doi:10.1038/npp.2017.209. ISSN 0893-133X. PMC 5719112. PMID 28875990.

Mechoulam R, Parker LA, Gallily R (November 2002). “Cannabidiol: an overview of some pharmacological aspects”. Journal of Clinical Pharmacology. 42 (11 Suppl): 11S–19S. doi:10.1002/j.1552-4604.2002.tb05998.x. PMID 12412831.

“Epidiolex (Cannabidiol) FDA Label” (PDF). fda.gov. Retrieved June 28, 2018. For label updates see FDA index page for NDA 210365

“FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy”. US Food and Drug Administration. June 25, 2018. Retrieved June 25, 2018.

Scuderi C, Filippis DD, Iuvone T, Blasio A, Steardo A, Esposito G (May 2009). “Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders”. Phytotherapy Research (Review). 23 (5): 597–602. doi:10.1002/ptr.2625. PMID 18844286.

Iseger TA, Bossong MG (March 2015). “A systematic review of the antipsychotic properties of cannabidiol in humans”. Schizophrenia Research. 162 (1–3): 153–61. doi:10.1016/j.schres.2015.01.033. PMID 25667194.

Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M (July 2017). “Cannabidiol: State of the art and new challenges for therapeutic applications”. Pharmacol. Ther. 175: 133–150. doi:10.1016/j.pharmthera.2017.02.041. PMID 28232276.

Stockings E, Zagic D, Campbell G, Weier M, Hall WD, Nielsen S, Herkes GK, Farrell M, Degenhardt L (July 2018). “Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence”. J. Neurol. Neurosurg. Psychiatry. 89 (7): 741–753. doi:10.1136/jnnp-2017-317168. PMID 29511052.

Blessing EM, Steenkamp MM, Manzanares J, Marmar CR (October 2015). “Cannabidiol as a Potential Treatment for Anxiety Disorders”. Neurotherapeutics. 12 (4): 825–36. doi:10.1007/s13311-015-0387-1. PMC 4604171. PMID 26341731.

Iffland K, Grotenhermen F (2017). “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies”. Cannabis and Cannabinoid Research. 2 (1): 139–154. doi:10.1089/can.2016.0034. PMC 5569602. PMID 28861514.

Prud’homme M, Cata R, Jutras-Aswad D (2015). “Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence”. Substance Abuse. 9: 33–8. doi:10.4137/SART.S25081. PMC 4444130. PMID 26056464.

Lucas, Catherine J.; Galettis, Peter; Schneider, Jennifer (November 2018). “The pharmacokinetics and the pharmacodynamics of cannabinoids: The pharmacokinetics and the pharmacodynamics of cannabinoids”. British Journal of Clinical Pharmacology. 84 (11): 2477–2482. doi:10.1111/bcp.13710. PMC 6177698. PMID 30001569.

Mechoulam R, Peters M, Murillo-Rodriguez E, Hanus LO (August 2007). “Cannabidiol–recent advances”. Chemistry & Biodiversity (Review). 4 (8): 1678–92. doi:10.1002/cbdv.200790147. PMID 17712814.

Russo, E. B. (2008). “Cannabinoids in the management of difficult to treat pain”. Therapeutics and Clinical Risk Management. 4 (1): 245–259. doi:10.2147/TCRM.S1928. PMC 2503660. PMID 18728714.

Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). “Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract”. Ther Drug Monit. 27 (6): 799–810. doi:10.1097/01.ftd.0000177223.19294.5c. PMID 16306858.

“FDA Regulation of Cannabis and Cannabis-Derived Products: Questions and Answers”. US Food and Drug Administration. April 2, 2019. Retrieved May 18, 2019.

“FDA warns company marketing unapproved cannabidiol products with unsubstantiated claims to treat cancer, Alzheimer’s disease, opioid withdrawal, pain and pet anxiety”. US Food and Drug Administration. July 23, 2019. Retrieved July 24, 2019. “Unlike drugs approved by the FDA, the manufacturing process of these products has not been subject to FDA review as part of the drug approval process, and there has been no FDA evaluation of whether these products are effective for their intended use, what the proper dosage is, how they could interact with FDA-approved drugs, or whether they have dangerous side effects or other safety concerns.”

Jones PG, Falvello L, Kennard O, Sheldrick GM, Mechoulam R (1977). “Cannabidiol”. Acta Crystallogr. B. 33 (10): 3211–3214. doi:10.1107/S0567740877010577.

Fox A, Ravitz JR, Leongini EM, Brian J M. “Companies Marketing CBD Products Be Warned: FDA Is Watching”. Lexology. Retrieved December 14, 2017.

Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E (February 2006). “Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors”. Naunyn-Schmiedeberg’s Archives of Pharmacology. 372 (5): 354–61. doi:10.1007/s00210-006-0033-x. PMID 16489449.

“Warning Letters and Test Results for Cannabidiol-Related Products”. Food and Drug Administration. November 2, 2017. Retrieved January 2, 2018.

“DEA reschedules Epidiolex, marijuana-derived drug, paving the way for it to hit the market”. CNBC. September 27, 2018.

Sachs J, McGlade E, Yurgelun-Todd D (October 2015). “Safety and Toxicology of Cannabinoids”. Neurotherapeutics. 12 (4): 735–46. doi:10.1007/s13311-015-0380-8. PMC 4604177. PMID 26269228.

Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R (October 2009). “Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb”. Trends in Pharmacological Sciences. 30 (10): 515–27. doi:10.1016/j.tips.2009.07.006. PMID 19729208.

Angelica LaVito, Thomas Franck (February 15, 2019). “New York City plans to fine restaurants using CBD in food and drinks”. CNBC. Retrieved February 19, 2019.

“Health products containing cannabis or for use with cannabis: Guidance for the Cannabis Act, the Food and Drugs Act, and related regulations”. Government of Canada. July 11, 2018. Retrieved October 19, 2018.

Conaway, K. Michael (December 20, 2018). “Text – H.R.2 – 115th Congress (2017-2018): Agriculture Improvement Act of 2018”. www.congress.gov. Retrieved May 1, 2019.

Stephen Daniells (November 6, 2018). “Top FDA official: ‘Anyone who thinks CBD is lawful is mistaken'”. NutraIngredients-USA, William Reed Business Media Ltd. Retrieved November 6, 2018.

“Warning Letters and Test Results for Cannabidiol-Related Products”. US Food and Drug Administration. April 2, 2019. Retrieved July 24, 2019.

“FDA and Marijuana: Questions and Answers. No. 12 – Can products that contain THC or cannabidiol (CBD) be sold as dietary supplements?”. US Food and Drug Administration. December 20, 2018. Retrieved January 13, 2019.