What Are SARMs and How Do They Work? The Ultimate Guide to SARMs

ELV Bioscience’s CGMP Production Facility

Buy SARMs

Selective Androgen Receptor Modulators (SARMs) have been a topic of interest within the biotechnology, pharmaceutical, medical, (and of course, performance enhancement) communities since the mid-90s when they were first presented in the field of science. However, during the 1940s, an initial class of SARMs (steroidal SARMs) were investigated by way of modification of the hormone testosterone. They have been utilized for therapeutic applications in treating numerous ailments including hypogonadism, cancer, osteoporosis, and different infections that influence muscle and bone wasting. These steroidal SARMs had a substantial impact on the growth of muscle tissue because of their strong binding affinity for the androgen receptors on skeletal muscle. However, due to this generation of SARMs being steroidal, they had other effects systemically – many of which were in the form of undesirable side effects, such as gynecomastia, endocrine disruption, sexual side effects, cardiovascular complications, prostate enlargement, as well as liver and kidney damage.

Selective Androgen Receptor Modulators (SARMs) have been a topic of interest within the biotechnology, pharmaceutical, medical, (and of course, performance enhancement) communities since the mid-90s when they were first presented in the field of science. However, during the 1940s, an initial class of SARMs (steroidal SARMs) were investigated by way of modification of the hormone testosterone. They have been utilized for therapeutic applications in treating numerous ailments including hypogonadism, cancer, osteoporosis, and different infections that influence muscle and bone wasting. These steroidal SARMs had a substantial impact on the growth of muscle tissue because of their strong binding affinity for the androgen receptors on skeletal muscle. However, due to this generation of SARMs being steroidal, they had other effects systemically – many of which were in the form of undesirable side effects, such as gynecomastia, endocrine disruption, sexual side effects, cardiovascular complications, prostate enlargement, as well as liver and kidney damage.

Ultimate Guide to SARMs:

With age, both men and women experience alterations and declines in hormone levels. This can lead to decreases in skeletal muscle mass, loss of bone density, loss of libido, and many other issues such as increases in body fat mass. In more extreme cases certain diseases can cause severe muscle wasting. SARMs are being developed and investigated to help preserve and increase skeletal muscle mass and bone density for individuals who may suffer from any of the aforementioned ailments, without the side effects of anabolic-androgenic steroids (AAS) or steroidal SARMs. The selectivity of SARMs for skeletal muscle androgen receptors, rather than systemic androgen receptors, as well as their non-steroidal nature, promotes a lower side effect profile for a much broader therapeutic application to both males and females.

Like anabolic-androgenic steroids (AAS) there are many different SARMS. Some of the most relevant are:

S-4 (Andarine, GTx-007).
LGD-4033 (Ligandrol).
MK-2866 (Ostarine, GTx-024).
RAD-140 (Testolone).
LGD-3303.
S-23.
YK-11.

There are also several chemicals that are often mistakenly labeled as SARMs, which include:

GW-501516 (Cardarine) – A PPARδ receptor agonist.
SR-9009 (Stenabolic) – A Rev-ErbA receptor agonist.
MK-677 (Ibutamoren) – A long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue.

SARMs represent a milestone in pharmacology as it relates to benefiting many therapeutic areas, particularly skeletal muscle growth and bone density improvements. Furthermore, SARMs can assist in maintaining a more favorable ratio of muscle to body fat. It is not surprise that SARMs have become a significant topic in bodybuilding, fitness, sports, and “anti-aging” protocols.
SARMs are designed to have the advantages of anabolic steroids on skeletal muscle and bone density while decreasing many of the most troublesome side effects. SARMs have the following advantages:

• Less concern for liver or kidney toxicity than oral steroids, or steroidal SARMs.
• Less concern regarding prostate issues in men.
• Less effect on the HPTA axis (less endogenous hormone suppression).
• Comparable or stronger anabolic effects than testosterone.
• SARMs are unable to convert to estrogen or dihydrotestosterone.

As a summary of available research, SARMs have been shown to promote the following benefits:

• Prevent the loss of muscle mass.
• Increased lean body mass.
• Increased strength.
• Faster recovery from muscular and joint injuries.

By reading this brief guide to SARMs, you should now have a clearer idea of what SARMs are, how SARMs work, how SARMs are different from anabolic-androgenic steroids (AAS), and what benefits this may bring to people for treating various conditions. Furthermore, this brief now help you realize why so many athletes are interested in SARMs as a prospectively safer alternative to traditional steroids for performance enhancement.

ELV Bioscience is a leading SARMs supplier for research purposes. We have strict purity, potency, and quality control measures under which SARMs and our other products are manufactured. We are one of very few USA manufacturers of research chemical grade SARMs. ELV Bioscience is ISO9001 certified, and our facilities are FDA cGMP.

Buy SARMs Online

REFERENCES:

“Journal of Medicinal Chemistry – Nonsteroidal Selective Androgen Receptor Modulators (SARMs): Dissociating the Anabolic and Androgenic Activities of the Androgen Receptor for Therapeutic Benefit (ACS Publications).” ACS Publications Home Page. N.p., n.d. Web. 18 Aug. 2015.

“Preclinical Characterization of a (S)-N-(4-Cyano-3-Trifluoromethyl-Phenyl)-3-(3-Fluoro, 4-Chlorophenoxy)-2-Hydroxy-2-Methyl-Propanamide: A Selective Androgen Receptor Modulator for Hormonal Male Contraception: Endocrinology: Vol 150, No 1.” Endocrine Society Journals and Publications. N.p., n.d. Web. 18 Aug. 2015.

Bhasin, Shalender, and Ravi Jasuja. “Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies.” Current opinion in clinical nutrition and metabolic care 12.3 (2009): 232–240. PMC. Web.

“Design, Synthesis, and in Vivo SAR of a Novel Series of Pyrazolines As Potent Selective Androgen Receptor Modulators – Journal of Medicinal Chemistry (ACS Publications).” ACS Publications Home Page. N.p., n.d. Web. 18 Aug. 2015.

Hanada, Keigo, et al. “Bone Anabolic Effects of S-40503, a Novel Nonsteroidal Selective Androgen Receptor Modulator (SARM), in Rat Models of Osteoporosis.” Biological and Pharmaceutical Bulletin. N.p., Nov. 2003. Web. 14 Aug. 2015.

“Pharmacodynamics of Selective Androgen Receptor Modulators.” Journal of Pharmacology and Experimental Therapeutics. N.p., n.d. Web. 18 Aug. 2015.

“Selective Androgen Receptor Modulator (SARM) Treatment Prevents Bone Loss and Reduces Body Fat in Ovariectomized Rats – Springer.” Home – Springer. N.p., n.d. Web. 18 Aug. 2015.

Bhasin, Shalender, and Ravi Jasuja. “Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies.” Current opinion in clinical nutrition and metabolic care 12.3 (2009): 232-240. PMC. Web.

“Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats: Endocrinology: Vol 148, No 1.” Endocrine Society Journals and Publications. N.p., n.d. Web. 18 Aug. 2015.

“Pharmacological Characterization of AC-262536, a Novel Selective Androgen Receptor Modulator.” ScienceDirect.com | Science, Health and Medical Journals, Full Text Articles and Books. N.p., n.d. Web. 18 Aug. 2015.

“A Selective Androgen Receptor Modulator with Minimal Prostate Hypertrophic Activity Enhances Lean Body Mass in Male Rats and Stimulates Sexual Behavior in Female Rats – Springer.” Home – Springer. N.p., n.d. Web. 18 Aug. 2015.

“An Orally Active Selective Androgen Receptor Modulator is Efficacious on Bone, Muscle, and Sex Function with Reduced Impact on Prostate. – PubMed – NCBI.” National Center for Biotechnology Information. N.p., n.d. Web. 18 Aug. 2015.

“Novel, Non-steroidal, Selective Androgen Receptor Modulators (SARMs) with Anabolic Activity in Bone and Muscle and Improved Safety Profile. – PubMed – NCBI.” National Center for Biotechnology Information. N.p., n.d. Web. 18 Aug. 2015.

Vajda, Eric G., et al. “Pharmacokinetics and Pharmacodynamics of LGD-3303 [9-Chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an Orally Available Nonsteroidal-Selective Androgen Receptor Modulator.” Journal of Pharmacology and Experimental Therapeutics. N.p., Feb. 2009. Web.

Facebook
Twitter
LINKEDIN