20mg/mL – 30mL Bottle.
Cardarine for Sale. Buy GW-501516. PPARδ Agonist. [>99.8% Purity].
Inactive Ingredients: Solvent Matrix. Preservative.
GW-501516 (Cardarine) is a PPARδ receptor agonist, also known as Endurobol. Based on available research, GW-501516 (Cardarine) has shown to accelerate metabolic rate, and subsequently, the burning of body fat. GW-501516 (Cardarine) was created via a collaboration between Ligand Pharmaceuticals GlaxoSmithKline in the 1990s, initially in clinical development for the treatment of cardiovascular and metabolic diseases. GW-501516 (Cardarine) binds to and activates the peroxisome proliferator activator receptor delta (PPAR-delta). A variety of PPAR-delta is inside the skeletal muscle tissues, and activation of this receptor affects genes related to improved metabolic function and increased physical performance.
Peroxisome proliferator-activated receptor 8 (PPAR8) stimulation or over-expression in adipocytes leads to increased fatty acid oxidation, improved exercise tolerance, and resistance to obesity. GW-501516 is the fust highly selective syntl1etic PPAR8 agonist available. GW-501516 binds to human PPAR8 with an IC50 value of 1 nM and is at least 100-fold selective fo1 PPAR8 compared to PPARa and PPARy .2 Inobese primates, GW-501516 increases high-density lipoprotein cholesterol and apolipoprotein A- 1 specific reverse cholesterol transpo11.3 GW-501516 is, therefore, a model compound for a new type of obesity therapeutic, as well as a selective pharmacological tool for understanding lipid metabolism.
In currently available rat studies, binding of GW-501516 (Cardarine) to PPARδ promotes the recruitment of the co-activator PGC-1α. This PPARδ and co-activator complex, when active, up-regulates the expression of proteins involved in the process of energy expenditure. Similar studies performed in rats showed that GW-501516 (Cardarine) caused an increase in fatty acid metabolism in skeletal muscle tissue. Regarding improvement in metabolic parameters, GW-501516 (Cardarine) also showed evidence of protection against diet-induced obesity and type II diabetes. When further studies were performed in primates, GW-501516 had shown to increase HDL (high-density lipoprotein) and simultaneously lower VLDL (very-low-density lipoprotein)
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