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Kanna, or Sceletium Tortuosum, is a plant indigenous to South Africa with a long history of traditional use. Awareness and desire for this rare botanical product has recently spread across the world due to its unique properties. Kanna contains several alkaloids, namely mesembrine, mesebrenone, mesembrenol, and tortuosamine. Kanna is known traditionally for its mood elevating and calming effects, without sedation. Kanna’s alkaloids promote increases in serotonin production and activity in the brain. Simultaneously, Kanna alkaloids function as a phosphodiesterase type 4 inhibitor (PDE4i). This function helps provide Kanna with reported nootropic benefits inclusive of focus, motivation, and mild energy.